1. Molecular diversity preservation for drug discovery and diversity assessment.References:
1.1. MDPI project of samples collection and exchange
1.2. Diversity assessment
2. Chemical and biopharmaceutical information and informatics.
2.1. Online journals editorship, online publication and conference initials
2-2. Structure Database
2-3. One-Wedge Convention for Stereochemical Representation (This proposal was submitted to IUPAC in 1999)
3. The nature of the chemical processes
3-1. Theory. Similarity principle: Establish a new theory of structural stability and process spontaneity after rejection of Gibbs paradox statement in statistical mechanics. I call this new theory similarity principle. Apply similarity principle to experimental chemistry such as organic synthesis. Understand the nature of the chemical process. Apply similarity principle for diversity assessment, data reduction and compression.
4. Organic synthesis. Organic synthesis related to medicinal chemistry by applying MDPI structural database (www.molmall.org)
4.1. Combinatorial chemistry (building blocks and combinatorial synthesis).
4.2. Synthesis of bioactive compounds.
Chemical JournalsPart of Graduate Courses
2004. Cofounder and Publisher of International Journal of Environmental Research and Public Health ( http://www.mdpi.org/ijerph)
2003. Cofounder and Publisher of Marine Drugs ( http://www.mdpi.org/marinedrugs)
2002-2007. Editor-in-Chief of Molecular Diversity (http://www.springeronline.com/journal/11030/edboard)
2001. Cofounder and Publisher of Sensors (http://www.mdpi.org/sensors)
2000. Cofounder and Publisher of International Journal of Molecular Sciences (http://www.mdpi.org/ijms).
1999. Cofounder of Chemical Journal on Internet (http://www.mdpi.org/cji or http://www.chemistrymag.org/).
1999. Editor-in-Chief (up to 2003) and and Publisher of Entropy (http://www.mdpi.org/entropy).
1999. Editorial Board member of Huaxue Tongbao.
1996. Editor-in-Chief of Molecules (http://www.mdpi.org/molecules).
Chemical Conferences18-22 October 2004, First International Symposium on Marine Drugs (ISMD2004) 18-22 October 2004, Qingdao, China (http://www.mdpi.net/marinedrugs/ismd2004)
6-10 August 2004, Advisory Committee member of The Second Worldwide Chinese High-Tech Chemistry Conference (http://www.cioc.ac.cn/chitec.html)
29 May - 3 June 2004, International Coordinator of I3S 2004 (Second International Symposium on Sensor Science), Nanjing, China
16-20 June 2003, I3S 2003 ( First International Symposium on Sensor Science), Paris, France (http://www.mdpi.org/sensors/I3S).
15-18 July 2002, Executive Chairman of the Organizing Committee of ISFMS 2002 (International Symposium on Frontiers in Molecular Science 2002), Qingdao, China (http://www.mdpi.org/isfms2002).
1-5 April 2001, Organizer of the symposium "Electronic Chemistry Publishing" (ACS National Spring Meeting, San Diego, USA).
15-19 October 2000, International Advisory Committee member of The 2nd International Symposium for Chinese Medicinal (ISCMC 2000 Chengdu, China).
7-9 October 1998, International Advisory Committee member of Second Annual Conference on Strategies and Techniques for Identification of Novel Bioactive Compounds.Zurich, Switzerland.
19-23 July 1998, International Advisory Committee member of The 1st International Symposium for Chinese Medicinal (ISCMC 1998 Taipei, Taiwan).
1-30 September 1997 International Electronic Conference on Synthetic Organic Chemistry (ECSOC), http://www.mdpi.org/ecsoc/, September 1-30 annual conference since 1997.
Invited lectures at major international conferences10-12 June 2004, Wizards of OS 3, The Future of the Digital Commons (http://wizards-of-os.org/), 2004, Berlin, Germany.
Wednesday, 10 December 2003: General Debate: Plenary Session 1 15:00h-21:00h. Molecular Diversity Preservation International Talk.
10-12 December 2003, Active member of Scientific Information Working Group of the Summit of United Nations' The World Summit on the Information Society (http://www.itu.int/wsis), see also http://www.wsis-si.org.
2003. 4 times attended United Nations' The World Summit on the Information Society (http://www.itu.int/wsis) Preparatory Committee meetings (PrepComs) in Geneva and Paris.
11-14 April 2001, Kwangju, South Korea. 1st International Symposium on Macro-and Supramolecular Architectures and Materials (MAM-01): Biological and Sythetic Systems.
19-22 September 1999 Moscow, Russia. NATO Advanced Research Workshop: Frontiers in Molecular Diversity: From Biology to Material Science.
September 15-17,1999 Bangalore, India. The Drug Discovery Paradigm, NATIONAL SCIENCE SEMINAR COMPLEX, (Indian Institute of Science Campus) Title of the invited talk: Ugly Symmetry, Beautiful Diversity: Theory and Application to Molecular Diversity Assessment and Exploitation for Drug Discovery
August 22-26, 1999 New Orleans, Louisiana, USA."Tetrahedral Carbon's 125th Anniversary Symposium" (Cosponsored with HIST, Invited Papers Only), Division of Organic Chemistry, The 218th ACS National Meeting in New Orleans, Louisiana: Title of the talk: Ugly Symmetry
October 7-9, 1998 Zurich, Switzerland. Second Annual Conference on Strategies and Techniques for Identification of Novel Bioactive Compounds. Title of the invited talk: Molecular Diversity Preservation and Exploitation for Bioactivity Screenings.
Invited talks at many universities, companies and research institutes. (http://www.mdpi.org/lin/lin-le.htm)
Molecular spectroscopy (1982, 2 semester, Hefei, China).
Group theory (1982-83, 2 semesters, Hefei, China).
Computational chemistry (1982-83, 2 semesters, Intensive course in computer science, Hefei, China).
Catalysis and Catalyst Design (1982-1983, 2 semester, Hefei, China)
Heterogeneous Catalyst Characterization (1984, 1 semester, Lanzhou)
Japanese (1983-1984, 2 semesters, Lanzhou, China)
Electrochemistry (1987, 1 semester, U. of Louisville, USA)
Polymer Chemistry (1988, 1 semester, U. of Louisville, USA).
X-ray crystallography (1988, 1 semester, Experiments and data treatment, U. Louisville, USA).
Molecular Quantum Mechanics (1987, 1 semester, U. of Louisville, USA).
Biophysics (Protein NMR etc. 1988, 2 semesters , U. of Louisville, USA).
Passive and Active Circuits (Electronic Circuits, 1988, 1 semester, U. of Louisville, USA).
Electromagnetic Fields (1988, 1 semester, graduate course, Physics Department, U. of Louisville, USA).
Electromagnetic Radiation (1989, 1 semester, physics graduate course, U. of Louisville, USA).
German (1989-1991, 3 semesters, Zürich, Switzerland)
Organic Instrumental Analyses (1989-1990, 3 semesters, Prof. Simon, ETH-Zürich)
Biochemistry (1989-1990, 1 semester, Prof. Benner, ETH-Zürich).
Organic Synthesis (1990-1991, 2 semesters, Prof. Seebach, ETH-Zürich).
Bio-organic Chemistry (1991, 1 semester, Prof. Arigoni, ETH-Zürich).
Magnetic Resonance (1991-1992, 1 semester, Prof. Ernst, ETH-Zürich).
Statistical Mechanics and Molecular Simulation (1992, Prof. van Gunsteren, ETH-Zürich).