Presented at the New Swiss Chemical Society (NSCS) Fall Meeting, University of Lausanne, 15 October 1997.
(Abstract published in Chimia, 1997, 51, 596)


Medicinal Chemistry, Poster 30

Preserving Molecular Diversity for Drug Discovery

Shu-Kun Lin

Molecular Diversity Preservation International (MDPI)

Saengergasse 25, CH-4054 Basel (New Address: MDPI, Matthaeusstrasse 11, CH-4057 Basel) (Lin@mdpi.org)

What prices diversity? We argue that molecular diversity consists both chemical information and chemical substances of molecules.

Chemists contribute not only new knowledge but also new substances. However, more than 90% of compounds recorded in literature exist only on paper; they were discarded by chemists. With the development of high throughput screening technology in recent years, the acquisition of chemical samples by samples collection and combinatorial synthesis now become the bottleneck in the process of new drug discovery. The high quality of a chemical library relies on the distinct differences of both the structures and properties of the collected samples [1]. These compounds in isolated form are traditionally and still routinely prepared in the laboratories and isolated from natural sources. Among other strategies, the first journal of organic chemistry and natural product chemistry, Molecules (visit http://www.mdpi.org/molecule/), was launched by MDPI in 1995 to encourage authors to deposit their compound samples at MDPI center in Switzerland and distribute at reasonable prices worldwide. This example has been followed by six other chemistry journals so far (http://www.mdpi.org/forum.htm). The idea [2] of this program is to supply both chemical information as well as the chemical substances themselves.

References

[1]. S.-K. Lin, Molecular Diversity Assessment: Logarithmic Relations of Information and Species Diversity and Logarithmic Relations of Entropy and Indistinguishability after Rejection of Gibbs Paradox of Entropy of Mixing, Molecules 1996, 1, 57-67.

[2] S.-K. Lin, Guide to the Deposit of and Exchange of Compound Samples, ACS 212th National Meeting, Orlando, Florida, August 25-29, 1996.