1. Molecular diversity preservation for drug discovery and diversity assessment.

1-1-1. MDPI Guide to the deposit and exchange of compound samples. Presented at ACS 212th National Meeting, Orlando, Florida, August 25-29, 1996.
Chemical Abstracts: abstracts.htm#1-1-1

1-1-2. Molecular Diversity Preservation Strategies: The MDPI Project. Presented at the 36th IUPAC Congress, Geneva, Switzerland. 1997.

1-1-3. Chemical samples preservation and exchange. Lin, Shu-Kun. Molecular Diversity Preservation International, Basel, Switz. Book of Abstracts, 218th ACS National Meeting, New Orleans, Aug. 22-26 (1999), ENVR-111.
Chemical Abstracts: abstracts.htm#1-1-3

1-1-4. Disinfectants and virucides for preventing AIDS. Lin, Shu-Kun. Molecular Diversity Preservation International, Basel, Switz. Book of Abstracts, 218th ACS National Meeting, New Orleans, Aug. 22-26 (1999), MEDI-284.
Chemical Abstracts: abstracts.htm#1-1-4

Organizer (or member of the organizing committee):
CHI Second Annual Conference on Strategies and Techniques for Identification of Novel Bioactive Compounds. October 7-9, 1998 Zurich, Switzerland.
The First International Symposium for Chinese Medicinal (ISCMC 1998 Taipei), July 19-23, 1998, Taipei.
The Second International Symposium for Chinese Medicinal (ISCMC 2000), October 15-19, 2000, Chengdu, China

1-2-1. Lin, S. -K. Molecular Diversity Assessment: Logarithmic Relations of Information and Species Diversity and Logarithmic Relations of Entropy and Indistinguishability After Rejection of Gibbs Paradox of Entropy of Mixing. Molecules 1996, 1, 57-67. (download the paper in pdf format at http://www.unibas.ch/mdpi/lin/moldivpa.pdf).

1-2-2. Molecular diversity assessment and information theory. Also Book of Abstracts, 215th ACS National Meeting, Dallas, March 29-April 2 (1998), COMP-180. Publisher: American Chemical Society, Washington, D. C. CODEN: 65QTAA.

1-2-3. The Drug Discovery Paradigm, NATIONAL SCIENCE SEMINAR COMPLEX, (Indian Institute of Science Campus). September 15-17,1999 Bangalore, India.
Title of the invited talk: Ugly Symmetry, Beautiful Diversity: Theory and Application to Molecular Diversity Assessment and Exploitation for Drug Discovery

1-2-4. NATO Advanced School on Frontiers in Molecular Diversity: From Biology to Material Science
Title of the invited talk: Similarity,Complementarity, and Molecular Diversity Assessment, September 19-22, 1999 Moscow, Russia.

2. Chemical and biopharmaceutical information and informatics.

2-1-1. Journals and E-Conference

Molecules (ISSN 1420-3049, CODEN: MOLEFW) http://www.mdpi.org/molecules (Since 1996)
Entropy (ISSN 1099-4300, CODEN: ENTRFG) http://www.mdpi.org/entropy/ (Since 1999)
Chemical Journal on Internet, (ISSN 1523-1623, CODEN: CJIHAC) http://www.mdpi.org/cji or http://www.chemistrymag.org (Since 1999)
International Journal of Molecular Sciences (ISSN 1422-0067, CODEN: IJMCFK) http://www.mdpi.org/ijms or http://www.ijms.org (Since 2000)

ECSOC (http://www.mdpi.org/ecsoc/) sponsored by several pharmaceutical and chemical companies.

2-1-2. Authors' e-mail address and URL to be added to chemical abstracts. Lin, Shu-Kun. Molecular Diversity Preservation International, Basel, Switz. Book of Abstracts, 218th ACS National Meeting, New Orleans, Aug. 22-26 (1999), CINF-016.
Chemical Abstracts: abstracts.htm#2-1-2

2-1-3. An Opportunity for a First Chemistry Research Paper for College Students
Spring'00 CONFCHEM

2-1-4. Organizer of  the CINF sponsored symposium "Electronic Chemistry Publishing" at the Spring ACS meeting in San Diego (April 1-5, 2001).

2-2-1.Lin, S. -K.; Patiny, L. MolBank: First Fully Web-Based Publication of Chemical Reaction Data of Individual Molecules with Structure Search and Submission. Internet Journal of Chemistry, 2000, 3, 1. (http://www.mdpi.org/lin/molbank/).

2-2-2. MolMall (www.molmall.org) nonprofit project for chemical exchange. Patiny, Luc; Lin, Shu-Kun. Institute of Organic Chemistry, University Lausanne, Lausanne, Switz. Book of Abstracts, 219th ACS National Meeting, San Francisco, CA, March 26-30, 2000 (2000), CINF-066.
Chemical Abstracts: abstracts.htm#2-2-2

2-2-3. MolBank: Preservation and publication of chemical reaction data. (presented with the assistance of by Dr. Luc Patiny, the MolBank editor) 218th ACS National Meeting, New Orleans, Aug. 22-26 (1999), CINF-078.
Chemical Abstracts: abstracts.htm#2-2-3

2-3-1. One-Wedge Convention of Stereochemical Representation of Quadrivalent Centers. First International Electronic Conference on Synthetic Organic Chemistry (ECSOC-1), www.mdpi.org/ecsoc/, September 1-30,
1997.

2-3-2. Stereochemical representation by wedges and a one-wedge convention. Lin, Shu-Kun, http://mdpi.org/lin/, MDPI, Molecular Diversity Preservation International, Basel, Switz. Book of Abstracts, 218th ACS National Meeting, New Orleans, Aug. 22-26 (1999), ORGN-198.
Chemical Abstracts: abstracts.htm#2-3-2

2-3-3. One-Wedge Convention for Stereochemical Representations
Shu-Kun Lin, Luc Patiny, Andrey Yerin, Janusz L. Wisniewski and Bernard Testa
One-Wedge Convention for Stereochemical Representations. Enantiomer 2000, 5, 571-583. http://www.unibas.ch/mdpi/molecules/wedge/wedge2.pdf

3. Study the fundamental nature of the chemical processes by experimental studies (organic synthesis, etc.) and by developing a useful theory of structural stability and process spontaneity.

3-1-1. Recent Papers

Lin, S. -K. What Is a Molecule? Int. J. Mol. Sci. 2000, 1, 6-7 (http://www.mdpi.org/ijms/htm/i1010006.htm).

Lin, S. -K. Editorial: Diversity and Entropy. Entropy 1999, 1, 1-3 (http://mdpi.org/entropy/htm/e1010001.htm)

Lin, S. -K. Understanding structural stability and process spontaneity based on the rejection of the Gibbs paradox of entropy of mixing. Journal of Molecular Structure (Theochem), 1997, 398, 145-153. pages:145,146, 147,148,149,150,151,152,153.

Lin, S. -K. Gibbs paradox of entropy of mixing: Experimental facts, its rejection, and the theoretical consequences. Journal of Theoretical Chemistry, 1996, 1, 135-150. (download the paper in pdf format at http://www.unibas.ch/mdpi/lin/ejtc027.pdf).

Lin, S. -K. Correlation of Entropy with Similarity and Symmetry. Journal of Chemical Information and Computer Sciences, 1996, 36, 367-376. pages: 367,368,369,370,371,372,373,374,375,376.

3-1-2. Conference presentation

Three papers were presented at the Second International Congress on Theoretical Chemical Physics, New Orleans, Louisiana, April 9-13 1996:
Lin, S. -K. Negative Temperature of Electronic Motion in Atoms and Molecules.
Lin, S. -K. Informational Temperature Concept and the Nature of Self-organization.
Lin, S. -K. Gibbs Paradox of Entropy of Mixing: Experimental facts, Its Rejection, and the Theoretical Consequences.

Five papers were presented at the World Congress of Theoretically Oriented Chemists (WATOC 96), Jerusalem, Israel, July 7-12, 1996.Download the following five abstracts (5pp) in pdf format.
Lin, S. -K. Understanding structural stability and process spontaneity based on the rejection of the Gibbs paradox of entropy of mixing, Abstract Book p. 106.
Lin, S. -K. The nature of the chemical process. 2. Mixing and separation, Abstract Book p. 174.
Lin, S. -K. The nature of the chemical process. 3. Self-organization in hierarchical structures, Abstract Book p. 175.
Lin, S. -K. The nature of the chemical process. 4. Formation of the chemical bond, Abstract Book p. 176.
Lin, S. -K. The nature of the chemical process. 5. Deformation in energy transduction, Abstract Book p. 177.

Lin, S. -K. Symmetry Breaking Problem Resolved, The American Physical Society March 1997, Kansas City, MO, USA. Download the summary in html format.

3-1-2-1. Ugly Symmetry (invited talk) Lin, Shu-Kun. Molecular Diversity Preservation International, Basel, Switz. Book of Abstracts, 218th ACS National Meeting, New Orleans, Aug. 22-26 (1999), ORGN-227.
Chemical Abstracts: abstracts.htm#3-1-2-1

3-1-2-2. Similarity rule and complementarity rule (a talk). Lin, Shu-Kun. Molecular Diversity Preservation International, Basel, Switz. Book of Abstracts, 218th ACS National Meeting, New Orleans, Aug. 22-26 (1999), ORGN-449
Chemical Abstracts: abstracts.htm#3-1-2-2

3-1-2-3. Negative local thermodynamic temperature: Electronic motion. Lin, Shu-Kun. Molecular Diversity Preservation International, Basel, Switz. Book of Abstracts, 218th ACS National Meeting, New Orleans, Aug. 22-26 (1999), PHYS-242.
Chemical Abstracts: abstracts.htm#3-1-2-3

3-1-2-4. Similarity principle and rejection of Gibbs paradox. Lin, Shu-Kun. Molecular Diversity Preservation International, Basel, Switz. Book of Abstracts, 218th ACS National Meeting, New Orleans, Aug. 22-26 (1999), PHYS-244.
Chemical Abstracts: abstracts.htm#3-1-2-4

3-1-2-5. Symmetry principle and similarity principle. Lin, Shu-Kun. Molecular Diversity Preservation International, Basel, Switz. Book of Abstracts, 218th ACS National Meeting, New Orleans, Aug. 22-26 (1999), PHYS-245.
Chemical Abstracts: abstracts.htm#3-1-2-5

3-1-2-6. Entropy and information. Lin, Shu-Kun. Molecular Diversity Preservation International, Basel, Switz. Book of Abstracts, 218th ACS National Meeting, New Orleans, Aug. 22-26 (1999), PHYS-354.
Chemical Abstracts: abstracts.htm#3-1-2-6

Lin, S. -K. A Facile Synthesis of Quinoxaline-2,3-diones as NMDA Receptor Antagonists, Molecules, 1996, 1, 37-40. (download the paper in pdf format at http://www.unibas.ch/mdpi/lin/quinoxaline.pdf).

4.1. Combinatorial chemistry (building blocks and combinatorial synthesis).
Collaborator(s): Pharmaceutical companies and universities

4.2. Synthesis of bioactive compounds.
Collaborator(s): Pharma or agrochemical companies and universities

Lin, S. -K.; Rasetti, V. Synthesis of Benzospiro[5,6]undecane Derivatives as Inhibitors of Steroid 5-a-Reductase, Helvetica Chimica Acta, 1995, 78, 857-865.