The First MDPI Lecture

Dr. Jean-Pierre Vigneron
Laboratoire de Chimie des Interactions Moleculaires, CNRS,  College de France,  Paris
Supramolecular Bioorganic Chemistry: Nucleic Acids Recognition and Synthetic Vectors for Gene Transfer
Abstract: In the first part of the lecture it will be shown that suitably designed molecules of cyclo-bis-intercaland type bind preferentially to single-stranded regions in DNA. The second part will be devoted to the transfection properties of new synthetic vectors for gene transfer; the structural characteristics of supramolecular assemblies formed by these new
guanidinium-cholesterol reagents will be reported.
Date and Place
Friday June 11th, 1999, 10:30 AM, WSJ-210 Auditorium, Novartis, Basel, Switzerland.
Some related publications by the lecturer
1.     Supramolecular Chemistry1995, 5, 139.
        J. Am. Chem. Soc.1995, 117, 6822.
        Nucleic Acids Res. 1997, 25, 2574
        Bioorg. Med. Chem. Lett. 1998, 8, 601.
2.     Proc. Natl. Acad. Sci. USA 1996, 93, 9682.
        Proc. Natl. Acad. Sci. USA 1997, 94, 1651.
        Biogenic Amines 1998, 14, 537.
        Proc. Natl. Acad. Sci. USA 1999, in press
CV of  Dr. Jean-Pierre Vigneron
I was born in 1942 in Anjou,West of France.After studying chemistry at the Ecole Nationale Supérieure de Chimie de Paris, I did my PhD with Prof. A. Horeau and Prof. H. Kagan at the Collège de France in Paris. I became "Chargé de Recherche" at the Centre National de la Recherche Scientifique (CNRS) in 1969. IN 1975-1976 I joined Pr. R. Raphäel in Cambridge University (UK). When Pr. Horeau retired and Prof. J.-M. Lehn was elected at the chair of "Chimie des Interactions Moléculaires" at the Collège de France I decided to work with him on supramolecular chemistry. I became Directeur de Recherche at the CNRS in 1983. Over the last years I have been involved in the design of cyclo-bis-intercaland molecules and, more recently, of non-viral vectors for gene transfer.
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