Dibutyldichloro(1,10-phenanthroline-N¹,N¹⁰)tin

Chun Hu ^1,*, Rihong Tan ², Jianping Wang ¹, Yu Ji ¹ and Shengfu Wang ¹

¹Shenyang Pharmaceutical University, Shenyang 110015, P. R. China, Tel: +86-24-23843711-3352, Fax: +86-24-23896050, E-mail: [email protected]

²Teachers' College of Shenyang University, Shenyang 110015, P. R. China

Received: 5 May 2000 / Accepted: 21 February 2001 / Published: 25 March 2001

Diorganotin dihalide complexes with bidentate nitrogen ligands exhibit some pharmaceutical activities such as antitumour activity, antiviral activity and anti-microbiological activity[1-3], we have synthesized some diorganotin dihalide complexes with bidentate nitrogen ligands, one of which is dibutyldichloro(1,10-phenanthroline-N¹,N¹⁰)tin.

A solution of dibutyltin dichloride (1.22 g, 4 mmol) in benzene (20 ml) was added to a solution of 1,10-phenanthroline (0.72 g, 4 mmol) in benzene (20 ml). The mixture was refluxed for 4 h, the solid that appeared upon cooling was filtered and recrystallized from absolute ethanol to give the title compound as white crystal (1.82 g, 94%).

M.p. 190-193°C.

IR(KBr): 1620 (C=N), 1574, 1514 (C=C), 850 (C-H), 624, 594 (Sn-C).

¹H-NMR(CDCl₃, 250 MHz): 9.82 (dd, 2H, H-2 in aromatic ring), 8.71 (dd, 2H, H-4), 8.14 (s, 2H, H-5), 8.03 (dd, 2H, H-3), 1.60 (m, 4H, 2CH₂), 1.38 (m, 4H, 2CH₂), 1.06 (m, 4H, 2CH₂), 0.62 (t, 6H, 2CH₃).

Anal. cacl. for C₂₀H₂₆Cl₂N₂Sn (394.81): C 49.63, H 5.41, N 5.79; found: C 49.45, H 5.70, N 5.84.

References

1.	Crowe, A.J.; Smith, P.J.; Atassi, G. Chem. Biol. Interact. 1980, 32, 171-178.
2.	Ward, S.G.; Taylor, R.C.; Crowe, A.J.; Balzarini, J.; De Clercq, E. Appl. Organomet. Chem. 1989, 3, 431-436.
3.	Hu, C.; Wang, S.; Tan, R. J. Shenyang Pharm. Univ. 1990, 7, 111-114.

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