Thematic Special Issues on Plant Secondary Metabolites. Molecules (ISSN 1420-3049)
Special Issue on Alkaloids
[Call for Paper] [Editors] [Manuscript Submissions] [Review Papers] [Research Papers] [Published Papers]
Manuscript submission deadline: 30 June 2008

Guest Editors
Prof. Dr. Patrícia Valentao
Pharmacognosy Laboratory, Pharmacy Faculty, University of Oporto, R. Aníbal Cunha, 164, 4050 054 Porto, Portugal; E-mail:
Prof. Dr. Mariana Sottomayor
Department of Botany, Faculty of Sciences and Institute for Molecular and Cell Biology (IBMC) , University of Porto Rua do Campo Alegre, 823 4150-180 Porto, Portugal; Tel. + 351 22 6074900, Fax + 351 22 6099157; Email:


Manuscript submission

Manuscripts should be prepared according to the Instructions for Authors and submitted by e-mail to, with copy to the Guest Editor Prof. Dr. Patrícia Valentao, E-mail:, Prof. Dr. Mariana Sottomayor, E-mail:, and the Editor-in-Chief, Dr. Derek J. McPhee, E-mail: The subject title of the message should be "Manuscript for Special Issue on Alkaloids". Deadline for article submission: 30 June 2008 (Papers can be continuously submitted, processed, and if accepted, continuously published).

Review papers published or to be considered

Review manuscripts: Before writing their manuscripts, potential authors of review articles should forward the title and a short abstract to, with copy to the Guest Editors. We will then provide feedback on the suitability of the topic.

Open Access
Seung Ho Lee, Jong-Keun Son, Byeong Seon Jeong, Tae-Cheon Jeong, Hyeon Wook Chang, Eung-Seok Lee and Yurngdong Jahng *
College of Pharmacy, Yeungnam University, Gyeongsan 712-749 Korea
* Author to whom correspondence should be addressed; E-mail:
Received: 1 January 2008; in revised form 1 February 2008 / Accepted: 2 February 2008 / Published: 6 February 2008
Review: Progress in the Studies on Rutaecarpine
Molecules 2008, 13, 272-300 (PDF format 1116 K)

Open Access
Javier Palazón 1,*, Arturo Navarro-Ocaña 2, Liliana Hernandez-Vazquez 1 and Mohammad Hossein Mirjalili 3
1 Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Avda Diagonal 643, E-08028, Barcelona, Spain; E-mail:
2 Departamento de Alimentos y Biotecnologia, Facultad de Química, Universidad Nacional Autónoma de México, México DF, México; E-mail:
3 Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran; E-mail:
* Author to whom correspondence should be addressed; E-mail:
Received: 3 June 2008; in revised form: 12 August 2008 / Accepted: 14 August 2008 / Published: 18 August 2008
Review: Application of Metabolic Engineering to the Production of Scopolamine
Molecules 2008, 13, 1722-1742 (PDF format 1422 K); DOI: 10.3390/molecules13081722

Open Access
László F. Szabó
Department of Organic Chemistry, Semmelweis University, Hőgyes utca 7, H-1092 Budapest, Hungary; E-mail:
Received: 5 August 2008; in revised form: 24 August 2008 / Accepted: 26 August 2008 / Published: 27 August 2008
Review: Rigorous Biogenetic Network for a Group of Indole Alkaloids Derived from Strictosidine
Molecules 2008, 13, 1875-1896 (PDF format 414 K); DOI: 10.3390/molecules13081875

Type of the paper: Review
Tentative Title: Analysis of Isoquinoline Alkaloids by Liquid Chromatography Methods
Author: Monika Waskmundzka-Hajnos

Type of the paper: Review
Tentative Title: Selective Accounts on Bioactive Alkaloids from Marine Organisms
Author: Phil Crews
Department of Chemistry, University of California, 1156 High Street, Santa Cruz, CA 95064, USA

Molecules Manuscript ID: alkaloids-20071203-Sultana-pk
Type of the paper: Review
Title: Pharmacological and spectral studies on Quinoline Alkaloids from Skimmia laureola
Authors: Nighat Sultana*  and Ather Ata
Abstract: This review covers the introduction, pharmacological activities, the spectral features and biosynthesis of quinoline alkaloids in Skimmia laureola. The aim of the present study is to describe the pharmacological and spectral features of constituents of Skimmia laureola. The pharmacological properties of quinoline alkaloids have been investigated to a limited degree and as a result evidence of cytotoxic, phototoxic, mutagenic, antibacterial and anti-viral (HIV) activity has been observed. Individual presentations on various aspects of quinoline alkaloids have also appeared as book chapters or articles in journals. These constituents have attracted considerable interest due to their biological activity but only few publications have appeared on the spectral features of chemical constituents of the plant S. laureola.

Molecules Manuscript ID: alkaloids-20071204-Andraos-ca
Type of the paper: Review
Title: A Critical Appraisal of Various Total Syntheses of the Woodward Alkaloids with Respect to Green Chemistry Metrics
Authors: John Andraos
York University, Department of Chemistry, 4700 Keele Street, Toronto, ON M3J 1P3, CANADA
Abstract: This review gives a thorough up-to-date green metrics evaluation of the state-of-the-art in the achievement of total syntheses of the celebrated Woodward alkaloids quinine, lysergic acid, morphine, strychnine, reserpine, and colchicine by various research groups with respect to material efficiency and synthesis strategy parameters. In particular, synthesis plans are evaluated with respect to atom economy (AE), reaction mass efficiency (RME), molecular weight building up parameter, degree of convergence and degree of asymmetry using the synthesis tree algorithm. Simple template spreadsheet programs are introduced to calculate these parameters for linear and convergent plans using number of steps, number of input reagents, reaction yields and molecular weights of reagents, intermediates, and byproducts as the only input data. New concepts are introduced in this work which give a deeper understanding of synthesis strategy and design, namely hypsicity (oxidation level)
index, structure mapping, and fraction of sacrificial reagents.
Key references: Andraos, J. Org. Process Res. Develop. 2005, 9, 149
Andraos, J. Org. Process Res. Develop. 2005, 9, 404
Andraos, J. Org. Process Res. Develop. 2006, 10, 212
Andraos, J. Application of Green Metrics Analysis to Chemical Reactions and
Synthesis Plans in Green Chemistry Metrics (A. Lapkin and D.C. Constable, eds.)
Blackwell Scientific: Oxford, in press

Research papers

Open Access
Beata Jasiewicz
Faculty of Chemistry, A. Mickiewicz University, Grunwaldzka 6, 60-780 Poznań, Poland; E-mail:
Received: 4 December 2007 / Accepted: 30 December 2007 / Published: 9 January 2008
Communication: NMR Spectra of Sparteine N1-oxide and α-Isosparteine N-oxide
Molecules 2008, 13, 3-10 (PDF format 77 K)

Open Access
Jae Joon Lee 1, Chun Mei Jin 1, Young Kyoon Kim 2, Shi Yong Ryu 3, Sung Cil Lim 1 and Myung Koo Lee 1,*
1 College of Pharmacy and Research Center for Bioresource and Health, Chungbuk National University, 12, Gaeshin-dong, Heungduk-gu, Cheongju 361-763, Korea; E-mail: (Jae Joon Lee); (Chun Mei Jin); (Sung Cil Lim)
2 College of Forest Science, Kookmin University, Seoul 136-702, Korea; E-mail: (Young Kyoon Kim)
3 Korea Research Institute of Chemical Technology, Taejeon 305-606, Korea; E-mail: (Shi Yong Ryu)
* Author to whom correspondence should be addressed. E-mail:; Tel: +82-43-262-2822, Fax: +82-43-276-2754.
Received: 30 January 2008; in revised form: 22 February 2008 / Accepted: 25 February 2008 / Published: 27 February 2008
Full Paper: Effects of Anonaine on Dopamine Biosynthesis and L-DOPA-Induced Cytotoxicity in PC12 Cells
Molecules 2008, 13, 475-487 (PDF format 132 K)
Open Access
Ernesto Fattorusso, Adriana Romano, Fernando Scala and Orazio Taglialatela-Scafati *
Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II”, Via D. Montesano 49, 80131 Napoli, Italy.; E-mails:;;
* Author to whom correspondence should be addressed. Tel. +39-081678509; E-mail:
Received: 25 June 2008 / Accepted: 16 July 2008 / Published: 17 July 2008
Article: Simplexidine, a 4-Alkylpyridinium Alkaloid from the Caribbean Sponge Plakortis simplex
Molecules 2008, 131465-1471 (PDF format 206 K); DOI: 10.3390/molecules13071465
Open Access
Alexandra CH F Sawaya 1,2,*, Ilka Nacif Abreu 3,4, Nathalia Luiza Andreazza 3, Marcos N. Eberlin 1 and Paulo Mazzafera 3
1 ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, State University of Campinas - UNICAMP, Campinas, SP, Brazil
2 Bandeirante University of São Paulo, UNIBAN, São Paulo, SP, Brazil
3 Department of Plant Physiology, Institute of Biology, State University of Campinas - UNICAMP, Campinas, SP, Brazil
4 Umeå Plant Science Centre – Umeå – Sweden
* Author to whom correspondence should be addressed; e-mail:; UNIBAN,Rua Maria Cândida 1813, Vila Guilheme, São Paulo, CEP 02071-013, SP, Brazil, Phone: +55-11-2967-9147; Fax: +55-11-4412-5871.
Received: 28 May 2008; in revised form: 22 June 2008 / Accepted: 18 July 2008 / Published: 30 July 2008
HPLC-ESI-MS/MS of Imidazole Alkaloids in Pilocarpus microphyllus
Molecules 2008, 13, 1518-1529 (PDF format 335 K); DOI: 10.3390/molecules13071518
Open Access
Sabira Begum*, Syed Nawazish Ali, Farhat, Syed Imran Hassan and Bina S. Siddiqui
H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan; E-mails: (Syed Nawazish Ali); (Farhat); (Syed Imran Hassan); (Bina S. Siddiqui)
* Author to whom correspondence should be addressed; E-mail:,; Tel.: +92-21-4824901; Fax: +92-21-4819018/4819019
Received: 6 May 2008; in revised form: 24 June 2008 / Accepted: 23 July 2008 / Published: 6 August 2008
Article: A Simple, Rapid and Mild One Pot Synthesis of Benzene Ring Acylated and Demethylated Analogues of Harmine under Solvent-free Conditions
Molecules 2008, 13, 1584-1598 (PDF format 217 K); DOI: 10.3390/molecules13081584

Type of the paper: Article
Tentative Title: Chemptothecinoids from the seeds of Nothapodytes foetida
Author: Dr. Fang-Rong Chang, Professor / Director, Graduate Institute of Natural Products, School of Pharmacy
Kaohsiung Medical University, Kaohsiung 807, Taiwan
Tel: +886-7-3121101p2162, Fax: +886-7-3114773

Type of the Paper: Article
Tentative Title: Idenfication of Atropine in Transgenic Cannabis Roots by EC-CG/MS
Author: Antonio Segura
Dr. Antonio Segura Carretero
Profesor Titular
Dpto Química Analítica (Analytical Chemistry)
Facultad de Ciencias. Universidad de Granada (Faculty of Sciences, University of Granada)
C/Fuentenueva s/n
18071 Granada  (Spain)

Alkaloids papers published in Molecules before

Open Access
Evangelia N. Tzanetou 1, Konstantinos M. Kasiotis 1, Prokopios Magiatis 2 and Serkos A. Haroutounian 1,*
1 Chemistry Laboratory, Agricultural University of Athens, Iera odos 75, Athens 11855, Greece
2 Faculty of Pharmacy, Laboratory of Pharmacognosy and Natural Products Chemistry, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece
* Author to whom correspondence should be addressed; E-mail:
Received: 13 March 2007; in revised form: 25 March 2007 / Accepted: 27 March 2007 / Published: 10 April 2007
Full Paper: Synthesis of (R)-Dihydropyridones as Key Intermediates for an Efficient Access to Piperidine Alkaloids
Molecules 2007, 12, 735-744 (PDF format 99 K)

Open Access
Juan M. Ruiz, María M. Afonso and J. Antonio Palenzuela*
Instituto Universitario de Bio-Orgánica “Antonio González”, Departamento de Química Orgánica, Universidad de La Laguna, 38206 La Laguna, Tenerife, Spain
* Author to whom correspondence should be addressed. E-mail:
Received: 25 January 2007; in revised form: 13 February 2007 / Accepted: 13 February 2007 / Published: 19 February 2007
Full Paper: Synthesis of 2,5-Disubstituted Octahydroquinolin-4-ones via an Intramolecular Hetero Diels-Alder Reaction
Molecules 2007, 12, 194-204 (PDF format 79 K)

Open Access
Çigdem Yolacan 1, Emine Bagdatli 1, Nüket Öcal 1,* and Dieter E. Kaufmann 2,*
1 Yıldız Technical University, Faculty of Art and Sciences, Department of Chemistry, Davutpasa Campus, 34210, Istanbul, Turkey
2 Clausthal University of Technology, Institute of Organic Chemistry, Leibnizstr. 6, D-38678 Clausthal-Zellerfeld, Germany
* Authors to whom correspondence may be addressed; e-mails:;
Full Paper: Epibatidine Alkaloid Chemistry: 5. Domino-Heck Reactions of Azabicyclic and Tricyclic Systems
Molecules 2006, 11, 603-614 (PDF format 77 K)

Open Access
I. Southwell
NSW Department of Primary Industries, Wollongbar Agricultural Institute, Australia
Review: 25 Years of Natural Product R&D with New South Wales Agriculture
Molecules 2005, 10, 1232-1241 (PDF format 219 K)

Open Access

Haruaki Ishiyama, Masashi Tsuda, Tadashi Endo and Jun’ichi Kobayashi*
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. Tel: (+81) 11-706-4985, Fax: (+81) 11-706-4989.
* Author to whom correspondence should be addressed; e-mail:
Asymmetric Synthesis of Double Bond Isomers of the Structure Proposed for Pyrinodemin A and Indication of Its Structural Revision
Molecules 2005, 10, 312–316 (PDF format 192 K)

Open Access
Rafael Chinchilla, Patricia Mazón and Carmen Nájera*
Departamento de Química Orgánica and Instituto de Síntesis Orgánica (ISO), Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain. Tel.: (+34) 965 903728, Fax: (+34) 965 903549.
*Author to whom correspondence should be addressed; E-mail:
Polymer-Supported Cinchona Alkaloid-Derived Ammonium Salts as Recoverable Phase-Transfer Catalysts for the Asymmetric Synthesis of α-Amino Acids
Molecules 2004, 9, 349-364 (PDF format 220 K)

Open Access
Gy. Hajós a,*, Zs. Riedl a, G. Timári a,&, P. Mátyus b, B. U. W. Maes c and G. L. F. Lemière c
a Institute of Chemistry, Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri út 59, H-1025 Budapest, Hungary.
b Institute of Organic Chemistry, Semmelweis University, H-1092 Budapest, Hogyes E. u. 7., Hungary.
c Department of Chemistry, University of Antwerp (RUCA), Groenenborgerlaan 171, B-2020, Antwerpen, Belgium.
& Present address: CHINOIN Pharmaceutical Works Co. Ltd, H-1325 Budapest, PO Box 110, Hungary.
* Author to whom correspondence should be addressed. E-mail:
Synthesis of New Polyfused Heterocycles of Biological Importance by Means of Pd(0) Catalysis
Molecules 2003, 8, 480-487 (PDF format 149 K)

Open Access
I. Ugi 1,*, B. Werner 1 and A. Dömling 2
1 Institute of Organic Chemistry and Biochemistry, Technical University of München, D-85747 Garching, Germany, Tel. +49-89-289-13229, Fax +49-89-289-13249.
2 Morphochem A.G., Gmunder Street 37 – 37a, D-81379 München, Germany, Tel. +49-89-78005-0 Fax +49-89-78005-555, e-mail:
Dedicated to the memory of Prof. Wang Yu
* Author to whom correspondence should be addressed: e-mail:
Invited Lecture and Review: The Chemistry of Isocyanides, their MultiComponent Reactions and their Libraries
Molecules 2003, 8, 53-66 (PDF format 299 K)

Also see the papers alkaloids papers publisehd in Marine Drugs.

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Last update: 10 September 2008