Special Issue "Neglected Diseases: Medicinal Chemistry and Natural Product Chemistry"
[Call for Papers] [Aims] [List of Keywords]
Deadline for paper submission: 30 June 2009

This special issue will focus on the top-ten neglected diseases as defined by the World Health Organization:

• Human African Trypanosomiasis (HAT or sleeping sickness)
• Chagas disease
• Dengue
• Leishmaniasis
• Leprosy
• Lymphatic filariasis (Elephantiasis)
• Malaria
• Onchocerciasis (River Blindness)
• Schistosomiasis ( Bilharzia)
• Tuberculosis

Tropical medicine, infectious diseases, medicinal chemistry

Manuscripts should be prepared according to the Instructions for Authors (http://www.mdpi.org/molecules/publguid.htm) and submitted before 30 June 2009
by e-mail to molecules@mdpi.org with a copy to ... and mcphee@mdpi.org. The subject title of the message should be
"Manuscript for Special Issue on Natural Products for Neglected Diseases".

1. Andrade-Cetto, A. Neglected diseases in Africa: a challenge for medicinal plants research. African Journal of Traditional, Complementary and Alternative Medicines 2005, 2, 213-214.
2. Basso, L.A.; Silva, L.H.P.; Fett-Neto, A.G. et al. The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases – a review. Mem. Inst. Oswaldo Cruz 2005, 100, 575-606.
3. Batista, R.; Humberto, J.L.; Chiari, E.; Oliveira, A.B. Synthesis and trypanocidal activity of ent-kaurane glycosides. Bioorg. Med. Chem. 2007, 15, 381-391.
4. Butler, M.S. Natural products to drugs: natural product derived compounds in clinical trials. Nat. Prod. Rep. 2005, 22, 162-195.
5. Chan-Bacab, M.J.; Peña-Rodríguez, L.M. Plant natural products with leishmanicidal activity Nat. Prod. Rep. 2001, (6), 674-688.
6. Dardonville, C. Recent advances in antitrypanosomal chemotherapy: patent literature 2002 – 2004. Expert Opin. Ther. Pat. 2005, 15, 1241-1257.
7. De Deken, R.;  Speybroeck, N.; Gillain, G.; Sigue, H.; Batawi, K.; Van Den Bossche, P. The macrocyclic lactone “spinosad,” a promising insecticide for tsetse fly control. J. Med. Entomol. 2004, 41, 814-818.
8. Fournet, A.; Munoz, V. Natural products as trypanocidal, antileishmanial and antimalarial drugs. Curr. Top. Med. Chem. 2002, 2, 1215-1237.
9. Krettli, A.U.; Andrade-Neto, V.F.; Brandão, M.G.L.; Ferrari, W.M.S. The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review. Mem. Inst. Oswaldo Cruz 2001, 96, 1033-1042.
10. Maes, L.; Vanden Berghe, D.; Germonprez, N.; Quirijnen, L.; Cos, P.; De Kimpe, N.; Van Puyvelde, L. In vitro and in vivo activities of a triterpenoid saponin extract (px-6518) from the plant Maesa balansae against visceral Leishmania species. Antimicrob. Agents Chemother. 2004, 48, 130–136.
11. Morel, C.M.; Acharya, T.; Broun, D. et al. Health innovation: the neglected capacity of developing countries to address neglected diseases. Science 2005, 309, 401-404.
12. Paterson, I.; Anderson, E.A. Chemistry: the renaissance of natural products as drug candidates. Science 2005, 310, 451-453.
13. Pecoul, B.; Chirac, P.; Trouiller, P.; Pond, J. Access to essential drugs in poor countries: a lost battle? J. Am. Med. Assoc. 1999, 281, 361-367.
14. Queiroz, E.F.; Ahua, K.M.; Hostettmann, K. Investigation of medicinal plants for the treatment of neglected diseases. Chimia 2005, 59, 299–302.
15. Sülsen, V.; Güida, C.; Coussio, J.; Paveto, C.; Muschietti, L.; Martino, V. In vitro evaluation of trypanocidal activity in plants used in Argentine traditional medicine. Parasitol. Res. 2006, 98, 370-374.
16. Trouiller, P.; Olliaro, P.; Torreele, E.; Orbinski, J.; Laing, R.; Ford, N. Drug development for neglected diseases: a deficient market and a public-health policy failure. The Lancet 2002, 359, 2188-2194.
17. Xiao, S.H.; Hui-Ming, W.; Tanner, M.; Utzinger, J.; Chong, W.  Tribendimidine: a promising, safe and broad-spectrum anthlemintic agent from China. Acta Tropica 2005, 94, 1-14.