(1 School of Chemical Engineering / Shaanxi Key Laboratory of Physico-Inorganic Chemistry, Northwest University, Xi'an Shaanxi 710069; 2Conservation technology department, the Palace Museum, Beijing 100009; 3 Department of Chemistry / Shaanxi Key Laboratory of Physico-Inorganic Chemistry, Northwest University, Xi'an Shaanxi 710069, China) Abstract The title compound was synthesized by mixing 2-amino-4,6-dimethoxylpyrimidine, potassium thiocyanate and ethyl chloroformate in ethyl acetate. It was characterized by IR and element analysis. The specific heat capacity (Cp)was determined by a microcalorimetry apparatus Micro-DSC III, and Cp=0.331+3.463×10-3T (293.0≤T≤344.2K).The constant-volume combustion energy of the compound, (), was determined as (16766.90 ±9.81) J·g-1 by a precise rotating-bomb calorimeter at 298.15K. Its standard molar enthalpy of combustion,, and standard molar enthalpy of formation, (), were calculated as (-4794.09 ± 2.81)kJ·mol-1 and(-1438.63 ±3.11)kJ·mol-1, respectively. Keywords synthesis; specific heat capacity; microcalorimetry; constant-volume combustion energy; standard molar enthalpy of formation Thioureas as a kind of highly active bactericide have been studied broadly for many years because they could prevent many crops from disease efficiently with little harm to crops and low toxicity to mammals [1]. Many research groups have made important contributions in this field [2-8]. The specific heat capacity is one of the essential thermodynamic data for substance, and importent to the relevant engineering technologic design of energies and materials. In this paper, the specific heat capacity and the constant-volume combustion energy of the title compound, 4-(4,6-dimethoxylpyrimidin-2-yl)-3-thio-allophonic acid ethyl ester, were determined by a microcalorimetry apparatus----Micro-DSC III and a precise rotating-bomb calorimeter respectively. Its standard molar enthalpy of combustion and standard molar enthalpy of formation were calculated on the basis of the constant-volume combustion energy of the compound. The final results would provide theoretical basis for enlarging their application field. 1. EXPERIMENTAL 2. RESULTS AND DISCUSSION The enthalpies of solution () of crystalline KCl (S.R.) in deionized water was measured at 298.15K. The result =17.267±0.074 kJ·mol-1 is in agreement with the recommended value reported in [10] (17.241±0.018 kJ·mol-1), which shows that the calorimetric system was reliable. Continuous heating model in Micro-DSC III apparatus was adopted in the experiment. It is convenient to measure the specific heat capacity of solid samples with this method. The specific heat capacity obtained by the experiments is a continuous variable temperature equation, and it is easy to deduce the specific heat capacity at a certain temperature according to the equation. The schematic diagram of Cp determination is shown in Fig.1.Calculated formula is as equation (1). (1) where Cp (J·g-1·K-1) is the heat specific capacity, As and Ab (W) are the real-time heat flows of the sample and the blank respectively, ms (g) is the mass of sample, b (K·s-1) is the heating rate. The software program of apparatus can deal with the data and figure out the results automatically. The determination results with 0.28877g sample and 0.1K·min-1 heating rate was shown in Fig.2. The specific heat capacity of the title compound is obtained as Cp=0.331+3.463×10-3T (293.0≤T≤344.2). Fig.1 Schematic diagram of continuous specific heat capacity Fig. 2 Determination results of the specific heat capacity 2.2 Combustion energy of the compound 2.2.1 Experimental condition The constant-volume combustion energy of the compound was determined by a precise rotating-bomb calorimeter (RBC-typeⅡ). The analytical methods and main experimental procedures were described previously [11]. The initial temperature was regulated to (25.0000 ± 0.0005) ℃, and the initial oxygen pressure was 2.5MPa. The correct value of the heat exchange was calculated according to Linio-Pyfengdelel-Wsava formula [12]. The calorimeter was calibrated with benzoic acid of 99.999% purity.(Chengdu Chemical Reagent Company), which has an isothermal heat of combustion of -2643 J·g-1 at 25℃. The calibrated experimental result was (17775.09±7.43) J·K-1 (Table 1), and the precision was 4.18×10-4. To determine the standard combustion energy of sulfur-containing compounds, the constant-volume combustion energy of thianthrene (mass fraction: 99%, recrystallized before using, Tokyo Kasei Kogyo Co. Ltd.) has been determined as being (-33507.76 ± 14.13) J·g-1 (Table 2), which suits well with the reported value as being(-33468 ± 4) J·g-1 . The precision and the accuracy were 4.22×10-4 and 1.19×10-3 , respectively. The analysis methods of the final products (gas, liquid and solid) were the same as these in ref.[11].The analytical results of the final products indicated that the combustion reactions were complete. The calibrated experimental results were summarized in Table 1. Table 1 Result for calibration of energy equivalent of the rotating-bomb calorimeter at 298.15K
2.2.2 Constant-volume combustion energy of the compound The methods of determination and calculation of the constant-volume combustion energy for the compound are the same as for the calibration of the calorimeter with benzoic acid. The values are calculated by the following equation: (2) Where (the title compound, s) denotes the constant-volume combustion energy of the compound (in J·g-1), W is the energy equivalent of the rotating-bomb calorimeter (in J·K-1 ), a is the length of the actual Ni-Cr wire consumed (in cm), G is the combustion enthalpy of Ni-Cr wire for ignition (0.9 J·cm1), 5.97 is the formation enthalpy and solution enthalpy of acid corresponding to 1mL of 0.1000mol·L-1 solution of NaOH (in J·mL-1), b is the volume (in mL) of consumed 0.1000 mol·L-1 solution of NaOH and is the correct value of the temperature rise. m is the mass (in g) of the title compound. The experiment results of the combustion energy of the compound were given in Table 2. Table 2 Experimental results for the combustion energies of the sample
2.2.3 Standard combustion enthalpy of the
compound Where The result of the calculation of is(-1438.63±3.11)KJ·mol-1. The standard molar enthalpy of formation of the compound is negative, which indicates that the compound's stability is better, and it is easy for preparation, reserve and application. REFERENCES [1] Wang D X., Bo Z S. New Pesticide Series.Wuhan: Central China Normal University Press, 1998 [2] Madan V K, Taneja A D. J. Indian. Chem. Soc. 1991, 68 (3):162 [3] Tang C C , Li Y, Chen B. Pesticide Chem.1988, 322 [4] Bowser A M. Tetrahedron Let. 2005, 46:2869 [5] Goodyear C L M. Bioorg. Med. Chem. 2003, 11:4189 [6] Harris J D, Eckles W E, Hepp A F, et al. Inorg. Chim. Acta. 2002, 338:99 [7] Sun X H, Gao R L, Liu Y F, et al. J. Chem. Engin.2003, 31(2):75 [8] REN Y H ,Song J R, Huang J, et al. Chin. J.Chem.2006, 24(2):219 [9] Kong F L, Wang L Q, Hu X H, et al .Huaxue Shijie.1991,(6):254 [10] Marthada, V. K. J. Res. Natl. Bur. Stand. 1980,85,467. [11] Yang X W, Chen S P, Gao S L. J. Instrumentation Science &Technology, 2002,30(3):311 [12] Popov M M.Thermometry and Calorimetry. Moscow: Moscow University Publishing House, 1954:382 [13] Rederick D R.Experimental thermochemistry, Moscow: Interscience Publishers Ltd.1956:88 [14] Robert C W.CRC Handbook of Chemistry and Physics, Carson City: Chemical Rubber Publishing Company, 1977-1978, 55:D45 化合物4-(4,6-二甲氧基嘧啶-2-基)-3-硫代脲酸乙酯的热化学性质研究 任莹辉1,宋纪蓉1,2,徐抗震1,马海霞1,黄洁1,傅丁薇1,杨旭武3 (1西北大学化工学院/陕西省物理无机化学重点实验室,陕西 西安 710069; 2故宫博物院文保科技部 北京 100009 ;3西北大学化学系/ 陕西省物理无机化学重点实验室,陕西 西安 710069) 摘要 用2-氨基-4,6-二甲氧基嘧啶,硫氰酸钾和氯甲酸乙酯在乙酸乙酯中反应合成了标题化合物,通过红外光谱和元素分析法对化合物进行表征。用Micro-DSC Ⅲ微量量热仪测定了化合物的比热容Cp=0.331+3.463×10-3T (293.0≤T≤344.2K)。在298.15K下,用精密转动弹热量计测定出化合物的恒容燃烧能为(16766.90±9.81) J·g-1,计算出标准摩尔燃烧焓和标准摩尔生成焓分别为(-4794.09 ± 2.81)KJ·mol-1和(-1438.63±3.11)KJ·mol-1 。 关键词 合成;比热容;微量量热仪;恒容燃烧能;标准摩尔生成焓 |
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