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Taiko Oda ^1,*,, Ayako Fujita ², Jinzhong Xu ^2,3, Masataka Mochizuki ¹, Kazuyo Ukai ³ and Michio Namikoshi ³
1 Kyoritsu University of Pharmacy, Shibakoen, Minato-ku, Tokyo 105-8512, Japan
E-mail: [email protected] (T. O.). E-mail: [email protected] (M. M.)
2 Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan
E-mail: [email protected] (A. F.). E-mail: [email protected] (J. X.)
3 Tohoku Pharmaceutical University, Komatsushima, Aoba-ku, Sendai 981-8558, Japan
E-mail: [email protected] (K. U.). E-mail: [email protected] (M. N.)
* Author to whom correspondence should be addressed. Tel., +81-3-5400-2497; fax, +81-3-5400-2497; e-mail: [email protected]
Received: 30 November 2006 / Accepted: 18 January 2007 / Published: 18 January 2007
Full Original Paper: Effects of Melophlins on Colony Formation of Chinese Hamster V79 Cells and IL-8 Production in PMA-stimulated HL-60 Cells
Mar. Drugs 2007, 5, 1-5 (PDF format 42 K); DOI: 10.3390/md20070001

 

Anake Kijjoa ^1,2,*, Rawiwan Wattanadilok ^2,3, Nair Campos ², Maria S�o Jos� Nascimento ⁴, Madalena Pinto ⁴ and Werner Herz ⁵
1 ICBAS-Instituto de Ci�ncias Biom�dicas Abel Salazar, Universidade do Porto, 4099-003 Porto, Portugal
2 Centro Interdisciplinar de Investiga��o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal
3 Bangsaen Institute of Marine Science (BIMS), Burapha University, Bangsaen, Chonburi 20131, Thailand
4 Centro de Estudos de Qu�mica Org�nica, Fitoqu�mica e Farmacologia da Universidade do Porto (CEQOFFUP), Faculdade de Farm�cia, Rua An�bal Cunha 164, 4050-047 Porto, Portugal
5 Department of Chemistry and Biochemistry, The Florida State University, Tallahassee, FL 32306-4390, USA
* Author to whom correspondence should be addressed; Email: [email protected]
Received: 26 March 2007 / Accepted: 4 April 2007 / Published: 17 April 2007
Full Original Paper: Anticancer Activity Evaluation of Kuanoniamines A and C Isolated from the Marine Sponge Oceanapia sagittaria, Collected from the Gulf of Thailand
Mar. Drugs 2007, 5, 6-22 (PDF format 126 K); DOI: 10.3390/md20070002


Gerhard Bringmann ^1,*, Tobias A. M. Gulder ¹, Gerhard Lang ^1,2, Stefanie Schmitt ¹, R�diger St�hr ², Jutta Wiese ², Kerstin Nagel ² and Johannes F. Imhoff ^2,*
1 Institut f�r Organische Chemie, Universit�t W�rzburg, Am Hubland, D-97074 W�rzburg, Germany
2 Marine Mikrobiologie, Leibniz-Institut f�r Meereswissenschaften, IFM-GEOMAR, D�sternbrooker Weg 20, D-24105 Kiel, Germany
* Authors to whom correspondence should be addressed; G.B. Tel. +49-931-8885323, Fax +49-931-8884755, E-mail: [email protected]; J.F.I. Tel. +49-431-6004450, Fax +49-431-6004452, E-mail: [email protected]
Dedicated to Prof. Dr. W.E.G. M�ller on the occasion of his 65th birthday
Received: 29 May 2007/ Accepted: 21 June 2007 / Published: 25 June 2007
Full Original Paper: Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A
Mar. Drugs 2007, 5, 23-30 (PDF format 89 K); DOI: 10.3390/md20070003
(This paper belongs to Special Issue: Marine Natural Products as Anti-Cancer Agents, edited by Prof. Dr. Jordan K. Zjawiony)


Baoquan Bao ^1,2, Ping Zhang ¹, Yoonmi Lee ¹, Jongki Hong ³, Chong-O. Lee ⁴ and Jee H. Jung ^1,*
1 College of Pharmacy, Pusan National University, Busan 609-735, Korea
2 College of Traditional Mongolian Medicine, Inner Mongolia University for the Nationalities, Tongliao Inner Mongolia 028000, China; E-mail: [email protected]
3 College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea
4 Korea Research Institute of Chemical Technology, Daejon 305-343, Korea
* Author to whom correspondence should be addressed. Tel., 82-51-510-2803; Fax: 82-51-513-6754; E-mail: [email protected]
Received: 5 June 2007 / Accepted: 23 June 2007 / Published: 25 June 2007
Full Original Paper: Monoindole Alkaloids from a Marine Sponge Spongosorites sp.
Mar. Drugs 2007, 5, 31-39 (PDF format 118 K); DOI: 10.3390/md20070004


Rawiwan Wattanadilok ^1,3, Pichan Sawangwong ², C�tia Rodrigues ^4,6, Honorina Cidade ^4,6, Madalena Pinto ^4,6, Eugenia Pinto ^5,6, Artur Silva ⁷ and Anake Kijjoa ^3,8,*
1 Bangsaen Institute of Marine Science (BIMS), Burapha University, Bangsaen, Chonburi 20131, Thailand
2 Department of Aquatic Science, Faculty of Sciences, Burapha University, Bangsaen, Chonburi 20131, Thailand
3 Centro Interdisciplinar de Investiga��o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal
4 Laborat�rio de Qu�mica Org�nica, Faculdade de Farm�cia, Universidade do Porto, Rua An�bal Cunha 164, 4050-047 Porto, Portugal
5 Laborat�rio de Microbiologia, Faculdade de Farm�cia, Universidade do Porto, Rua An�bal Cunha 164, 4050-047 Porto, Portugal
6 Centro de Estudos de Qu�mica Org�nica, Fitoqu�mica e Farmacologia da Universidade do Porto (CEQOFFUP), Rua An�bal Cunha 164, 4050-047 Porto, Portugal
7 Departamento de Qu�mica, Universidade de Aveiro, 4810-1933 Aveiro, Portugal
8 ICBAS-Instituto de Ci�ncias Biom�dicas Abel Salazar, Universidade do Porto, 4099-003 Porto, Portugal
* Author to whom correspondence should be addressed; Email: [email protected]
Received: 31 May 2007 / Accepted: 23 June 2007 / Published: 25 June 2007
Full Original Paper: Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand
Mar. Drugs 2007, 5, 40-51 (PDF format 110 K); DOI: 10.3390/md20070005

Manuel Mart�nez-Garc�a ^1,*, Marta D�az-Vald�s ², Alfonso Ramos-Espl� ², N�lida Salvador ³, Patricia Lopez ¹, Eduardo Larriba ¹ and Josefa Ant�n ¹
1 Divisi�n de Microbiolog�a, Universidad de Alicante, 03080 Alicante, Spain
2 Departamento de Ciencias del Mar y Biolog�a Aplicada, Universidad de Alicante, 03080 Alicante, Spain
3 Instituto Biomar, S. A. Pol. Ind. Edificio CEI 2.02, 24231 Onzonilla, Le�n, Spain
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 18 June 2007 / Accepted: 17 July 2007 / Published: 19 July 2007
Full Original Paper: Cytotoxicity of the Ascidian Cystodytes dellechiajei Against Tumor Cells and Study of the Involvement of Associated Microbiota in the Production of Cytotoxic Compounds
Mar. Drugs 2007, 5, 52-70 (PDF format 213 K); DOI: 10.3390/md20070006
(This paper belongs to Special Issue: Bioactive Compounds from Marine Microorganisms, edited by Dr. Ipek Kurtboke)

 

Maya P. Singh ^1,*, Jeffrey E. Janso ¹ and Sean F. Brady ^2,†
1 Natural Products Research, Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA; E-mail: [email protected]
2 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
† Current address: Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, NY 10021; E-mail: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 22 June 2007 / Accepted: 8 July 2007 / Published: 19 July 2007
Full Original Paper: Cytoskyrins and Cytosporones Produced by Cytospora sp. CR200: Taxonomy, Fermentation and Biological Activities
Mar. Drugs 2007, 5, 71-84 (PDF format 138 K); DOI: 10.3390/md20070007


Serena Leone ¹, Alba Silipo ¹, Evgeny L.Nazarenko ², Rosa Lanzetta ¹, Michelangelo Parrilli ¹ and Antonio Molinaro ^1,*
1 Dipartimento di Chimica Organica e Biochimica, Universit� degli studi di Napoli “Federico II”, via Cintia 4, I-80126 Napoli, Italy
2 Pacific Institute of Bioorganic Chemistry, Far-East Branch of the Russian Academy of Sciences, 690022 Vladivostok-22, Russian Federation
* Author to whom correspondence should be addressed. E-mail: [email protected]. Fax: +39-081-674393.
Received:  27 August 2007/ Accepted: 17 September 2007 / Published: 19 September 2007
Review: Molecular Structure of Endotoxins from Gram-negative Marine Bacteria: An Update
Mar. Drugs 2007, 5, 85-112 (PDF format 177 K); DOI: 10.3390/md20070008
(This paper belongs to Special Issue Marine Toxins edited by Dr. Alejandro Mayer)


Alejandro M. S. Mayer ^1,*, Marcio Guzman ², Renee Peksa ³, Mary Hall ⁴, Michael J. Fay ⁵, Peer B. Jacobson ⁶, Anne M. Romanic ⁷ and Sarath P. Gunasekera ⁸
1 Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA
2 Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA; E-mail: [email protected]
3 Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA; E-mail: [email protected]
4 Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA; E-mail: [email protected]
5 Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA; E-mail: [email protected]
6 Abbott Laboratories, Abbott Park, Illinois 60064, USA; E-mail: [email protected]
7 GlaxoSmithKline Pharmaceuticals, Department of Cardiovascular Pharmacology, King of Prussia, Pennsylvania 19406, USA; E-mail: [email protected]
8 Harbor Branch Oceanographic Institution, Division of Biomedical Marine Research, 5600 US 1 North, Fort Pierce, FL 34946, USA; E-mail: [email protected]
* Author to whom the correspondence should be addressed; Tel. 630 515 6951; Fax 630 515 6295. Email: [email protected].
Received: 24 August 2007 / Accepted: 20 September 2007 / Published: 24 September 2007
Full Original Paper: Differential Effects of Domoic Acid and E. coli Lipopolysaccharide on Tumor Necrosis Factor-α, Transforming Growth Factor-β1 and Matrix Metalloproteinase-9 Release by Rat Neonatal Microglia: Evaluation of the Direct Activation Hypothesis
Mar. Drugs 2007, 5, 113-135 (PDF format 749 K); DOI: 10.3390/md20070009
(This paper belongs to Special Issue Marine Toxins edited by Dr. Alejandro Mayer)

Issue 4  (December 2007)  pages 136-241

Yung Sung Cheng ^1,*, Yue Zhou ¹, C. Mitch Irvin ¹, Barbara Kirkpatrick ² and Lorraine C. Backer ³
1 Lovelace Respiratory Research Institute, 2425 Ridgecrest, SE, Albuquerque, NM, 87111, USA; E-mails: [email protected] (for Yue Zhou); [email protected] (C. Mitch Irvin)
2 Mote Marine Laboratory, 1600 Ken Thompson Parkway, Sarasota, FL 34236, USA; E-mail: [email protected]
3 National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Atlanta, GA, 30341,USA; E-mail: [email protected]
* Author to whom correspondence should be addressed; E-mail: [email protected]; Tel. +1 505-348-9410; Fax +1 505-348-8567
Received: 22 September 2007 / Accepted: 10 October 2007 / Published: 12 October 2007
Full Original Paper: Characterization of Aerosols Containing Microcystin

Mar. Drugs 2007, 5, 136-150 (PDF format 99 K); DOI: 10.3390/md20070010
(This paper belongs to Special Issue Marine Toxins edited by Dr. Alejandro Mayer)

Taiko Oda ^1,*, Weifang Wang ², Kazuyo Ukai ², Takahiro Nakazawa ² and Masataka Mochizuki ¹
1 Kyoritsu University of Pharmacy, Shibakoen, Minato-ku, Tokyo 105-8512, Japan
2 Tohoku Pharmaceutical University, Komatsushima, Aoba-ku, Sendai 981-8558, Japan
*Author to whom correspondence should be addressed: Tel. +81-3-5400-2497, Fax +81-3-5400-2497, E-mail: [email protected]
Received: 25 September 2007 / Accepted: 29 October 2007 / Published: 30 October 2007
Full Original Paper: A Sesquiterpene Quinone, 5-Epi-smenospongine, Promotes TNF-α Production in LPS-stimulated RAW 264.7 Cells

Mar. Drugs 2007, 5, 151-156 (PDF format 59 K); DOI: 10.3390/md20070011

Tom Turk ¹, Robert Frangež ² and Kristina Sepčić ^1,*
1 Department of Biology, Biotechnical Faculty, University of Ljubljana, Večna pot 111, 1000 Ljubljana, Slovenia; e-mail: [email protected]
2 Institute of Physiology, Pharmacology and Toxicology, Veterinary Faculty, Gerbičeva 60, University of Ljubljana, Slovenia; e-mail: [email protected]
* Author to whom correspondence should be addressed; e-mail: [email protected]; Fax: +38612573390, Tel: +38614233388.
Received: 16 October 2007 / Accepted: 31 October 2007 / Published: 13 November 2007
Review: Mechanisms of Toxicity of 3-Alkylpyridinium Polymers from Marine Sponge Reniera sarai

Mar. Drugs 2007, 5, 157-167 (PDF format 79 K); DOI: 10.3390/md20070012
(This paper belongs to Special Issue Marine Toxins edited by Dr. Alejandro Mayer)

Zouher Amzil ^1,*, Manoella Sibat ¹, Florence Royer ¹, Nadine Masson ² and Eric Abadie ³
1 IFREMER, Microbiology and Phycotoxins Department, BP 21105, 44311 Nantes, France; E-mails: [email protected], [email protected]
2 IFREMER, station d’Arcachon, Quai du Cdt Silhouette, 33120, Arcachon, France; E-mail: [email protected],
3 IFREMER, station de S�te, Avenue Jean Monnet, BP 171, 34203, S�te, France; E-mail: [email protected]
* Corresponding author: E-mail: [email protected]; Phone: (33) 2-40-37-40-69; Fax: (33) 2-40-37-40-73

Received: 16 October 2007 / Accepted: 21 November 2007 / Published: 23 November 2007
Full Research Paper: Report on the First Detection of Pectenotoxin-2, Spirolide-A and Their Derivatives in French Shellfish
Mar. Drugs 2007, 5, 168-179 (PDF format 136 K); DOI: 10.3390/md20070013
(This paper belongs to Special Issue Marine Toxins edited by Dr. Alejandro Mayer)

Sandra Anne Banack ^1,2, Holly E. Johnson ¹, Ran Cheng ¹ and Paul Alan Cox ^1,*
1 Institute for Ethnomedicine, Box 3464, Jackson Hole, Wyoming 83001, USA; E-mails: [email protected] (Sandra Anne Banack); [email protected] (Holly E. Johnson);
[email protected] (Ran Cheng)
2 Department of Biological Science, California State University, Fullerton, California 92834, USA
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: November 17, 2007 / Accepted: 4 December 2007 / Published: 6 December 2007

Full Original Paper: Production of the Neurotoxin BMAA by a Marine Cyanobacterium
Mar. Drugs 2007, 5, 180-196 (PDF format 373 K); DOI: 10.3390/md20070014

(This paper belongs to Special Issue Marine Toxins edited by Dr. Alejandro Mayer)

Vipra Kundoor ¹, Xiaoying Zhang ¹, Ajay Bommareddy ¹, Sherief Khalifa ², Hesham Fahmy ^1,* and Chandradhar Dwivedi ¹
1 Department of Pharmaceutical Sciences, South Dakota State University, Box 2202C, Brookings, SD 57007, USA. Tel.: 605-688-4243, Fax 605-688-5993.
2 Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
* Author to whom correspondence should be addressed; E-mail: [email protected]
Received: 2 October 2007 / Accepted: 11 December 2007 / Published: 12 December 2007
Full Research Paper: Chemopreventive Effects of Sarcotriol on Ultraviolet B-induced Skin Tumor Development in SKH-1 Hairless Mice

Mar. Drugs 2007, 5, 197-207 (PDF format 181 K); DOI: 10.3390/md20070015

Lora E. Fleming ^1,*, Eva Jerez ², Wendy Blair Stephan ², Amy Cassedy ³, Judy A Bean ³, Andrew Reich ⁴, Barbara Kirkpatrick ⁵, Lorraine Backer ⁶, Kate Nierenberg ⁵, Sharon Watkins ⁴, Julie Hollenbeck ¹ and Richard Weisman ²
1 NSF NIEHS Oceans and Human Health Center, Rosenstiel School of Marine and Atmospheric Sciences, University of Miami, Miami, FL 33136 USA
2 South Florida Poison Information Center, Department of Pediatrics, Miller School of Medicine, University of Miami, and Jackson Health Systems, Miami, FL 33136 USA
3 Biostatistics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45244 USA
4 Aquatic Toxins Group, Environmental Epidemiology, Florida Department of Health, Tallahassee, FL 32399-1712 USA
5 Mote Marine Laboratory, Sarasota, FL 34236 USA
6 National Center for Environmental Health (NCEH), Centers for Disease Control and Prevention (CDC), Atlanta, GA 30341 USA
* Author to whom correspondence should be addressed; e-mail: [email protected]; mailing address: Departments of Epidemiology & Public Health and Marine Biology & Fisheries (MBF)
University of Miami School of Medicine and Rosenstiel School of Marine and Atmospheric Sciences (RSMAS), Clinical Research Building (CRB), 10th Floor (R 669), 1120 NW 14th Street, Miami, FL 33136, USA; Tel: +1 305 243 5912' Fax: +1 305 243 3384
Received: 30 October 2007 / Accepted: 12 December 2007 / Published: 14 December 2007

Full Original Paper: Evaluation of Harmful Algal Bloom Outreach Activities
Mar. Drugs 2007, 5, 208-219 (PDF format 190 K); DOI: 10.3390/md20070016
(This paper belongs to Special Issue Marine Toxins edited by Dr. Alejandro Mayer)

John P. Bowman
Tasmania Institute of Agricultural Research, School of Agricultural Science, University of Tasmania, Sandy Bay, Private Bag 54, Hobart, Tasmania, 7001, Australia; E-mail: [email protected]
Received: 27 November 2007 / Accepted: 14 December 2007 / Published: 18 December 2007

Review: Bioactive Compound Synthetic Capacity and Ecological Significance of Marine Bacterial Genus Pseudoalteromonas
Mar. Drugs 2007, 5, 220-241 (PDF format 361 K); DOI: 10.3390/md20070017
(This paper belongs to Special Issue: Bioactive Compounds from Marine Microorganisms, edited by Dr. Ipek Kurtboke)

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