Table of Contents Volume 4, 2006
Marine Drugs ISSN 1660-3397, CODEN: MDARE6


Vol. 6, 2008Vol. 5, 2007 Vol. 4, 2006 Vol. 3, 2005
Vol. 2, 2004
Vol. 1, 2003

 

Issue 1 (March 2006) pages 1-27

Open Access (open access to this paper was granted by MDPI)
Jaine H. H. L. de Oliveira 1, Mirna H. R. Seleghim 1, Christoph Timm 2, Achim Grube 2, Matthias Köck 2, Gislene G.F. Nascimento 3, Ana Claudia T. Martins 3, Elissa G. O. Silva 3, Ana Olívia de Souza 4, Fabio C. S. Galetti 4, Paulo R. R. Minarini 4, Célio L. Silva 4, Eduardo Hajdu 5 and Roberto G. S. Berlinck 1,*
1 Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP, Brazil.
E-mail: jainehh@iris.ufscar.br for Jaine H. H. L. de Oliveira; E-mail: mirna@iqsc.usp.br for Mirna H. R. Seleghim
2 Alfred-Wegener-Institut für Polar- und Meeresforschung in der Helmholtz-Gemeinschaft, Am Handelshafen 12,D-27570 Bremerhaven, Germany.
E-mail: agrube@awi-bremerhaven.de for Achim Grube;E-mail: mkoeck@awi-bremerhaven.de for Matthias Köck
3 Faculdade de Ciências da Saúde, Universidade Metodista de Piracicaba, Piracaba, SP, Brazil.
E-mail: ggfranco@unimep.br for Gislene G.F. Nascimento
4 Laboratório de Bioquímica e Biofísica, Instituto Butantan, São Paulo, Brazil.
E.mail: olívia@butantan.gov.br for Ana Olívia de Souza
5 Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
E-mail: galetti@cpt.fmrp.usp.br for Fabio C. S. Galetti
6 Museu Nacional, Universidade Federal do Rio de Janeiro, Quinta da Boa Vista, s/n, 20940-040, Rio de Janeiro, RJ, Brazil.
E-mail: hajdu@acd.ufrj.br for Eduardo Hajdu
* Author to whom correspondence should be addressed; E-mail: rgsberlinck@iqsc.usp.br
Antimicrobial and Antimycobacterial Activity of Cyclostelletamine Alkaloids from Sponge Pachychalina sp.
Mar. Drugs 2006, 4, 1-8 (PDF format 50 K)

Open Access (open access to this paper was granted by MDPI)
Yusuke Wakuda 1, Takaaki Kubota 2, Hiroshi Shima 1,3, Tadashi Okada 1, Shinya Mitsuhashi 1, Naohito Aoki 4, Kunimi Kikuchi 1 and Jun'ichi Kobayashi 2,*
1 Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-0815, Japan
2 Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Tel. 81 11 706 4985. Fax 81 11 706 4989. E-mail: jkobay@pharm.hokudai.ac.jp.
3 Division of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Miyagi 981- 1293, Japan.
4 Department of Life Sciences, Faculty of Bioresources, Mie University, 1577 Kurimamachiya-cho, Tsu, Mie 514-8507 Japan
Short Communication: Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
Mar. Drugs 2006, 4, 9-14 (PDF format 148 K)

Open Access
Taiko Oda 1,*, Takeshi Fujiwara 2, Hongwei Liu 2,†, Kazuyo Ukai 2, Remy E. P. Mangindaan 3, Masataka Mochizuki 1 and Michio Namikoshi 2
1 Department of Pharmaceutical Sciences, Kyoritsu University of Pharmacy, Shibakoen, Minato-ku, Tokyo 105-8512, Japan
2 Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan
3 Faculty of Fisheries and Marine Science, Sam Ratulangi University, Kampus Bahu, Manado 95115, Indonesia
* Author to whom correspondence should be addressed: Tel. +81-3-5400-2497, Fax +81-3-5400-2497, E-mail: oda-ti@kyoritsu-ph.ac.jp
† Present address: Tsinghua University, Tsinghua Campus, The University Town, Shenzhen, Peoples Republic of China
Effects of Lissoclibadins and Lissoclinotoxins, Isolated from a Tropical Ascidian Lissoclinum cf. badium, on IL-8 production in a PMA-stimulated Promyelocytic Leukemia Cell Line
Mar. Drugs 2006, 4, 15-21 (PDF format 92 K)

Open Access
Taiko Oda 1,*, Jinzhong Xu 2, Ayako Fujita 2, Masataka Mochizuki 1 and Michio Namikoshi 2
1 Department of Pharmaceutical Sciences, Kyoritsu University of Pharmacy, Shibakoen, Minato-ku, Tokyo 105-8512, Japan
2 Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan
* Author to whom correspondence should be addressed: Tel. +81-3-5400-2497, Fax +81-3-5400-2497, E-mail: oda-ti@kyoritsu-ph.ac.jp
Effects of bistheonellide A, an Actin-polymerization Inhibitor, on Chinese Hamster V79 Cells and on IL-8 Production in PMA-stimulated HL-60 Cells
Mar. Drugs 2006, 4, 22-27 (PDF format 53 K)
Issue 2 (March 2006) 28-36

Open Access (open access to this paper was granted by MDPI)
Hesham Fahmy 1,*, Jordan K. Zjawiony 2,*, Takao Konoshima 3, Harukuni Tokuda 4, Shabana Khan 5, and Sherief Khalifa 6
1 Department of Pharmaceutical Sciences, South Dakota State University, Box 2202C, Brookings, SD 57007, USA.
Tel.: 605-688-4243, Fax 605-688-5993, E-mail: Hesham.Fahmy@sdstate.edu
2 Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA.
Tel.: 662-915-7290, Fax: 662-915-6975; E-mail: jordan@olemiss.edu
3 Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan
4 Department of Molecular Biochemistry, Kyoto Prefectural University of Medicine, Kawaramachidori, Kamigyo-Ku, Kyoto 602-0841, Japan
5 National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677-1848, USA
6 Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
* Authors to whom correspondence should be addressed
Potent Skin Cancer Chemopreventing Activity of Some Novel Semi-synthetic Cembranoids from Marine Sources
Mar. Drugs 2006, 4, 28-36 (PDF format 83 K)


Issue 3 (April 2006) 37-273

Special Issue: Marine Drugs and Ion Channels
Guest Editors: Hugo Rubén Arias

Open Access
Hugo R. Arias
Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California 91766, USA
Tel. (909) 469-5424, Fax (909) 469-5600, E-mail: harias@westernu.edu

Review: Marine Toxins Targeting Ion Channels
Mar. Drugs 2006, 4, 37-69 (PDF format 361 K)

Open Access (open access to this paper was granted by MDPI)
Shanta M. Messerli and Robert M. Greenberg *
Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA
Tel: 508 289-7981. E-mail: rgreenberg@mbl.edu
* Author to whom correspondence should be addressed.

Review: Cnidarian Toxins Acting on Voltage-Gated Ion Channels
Mar. Drugs 2006, 4, 70-81 (PDF format 97 K)

Open Access
Graham M. Nicholson 1,* and Richard J. Lewis 2
1 Neurotoxin Research Group, Department of Health Sciences, University of Technology, Sydney, PO Box 123, Broadway NSW 2007, Australia. Tel. 61 02 9514 2230. Fax 61 02 9514 2228.
E-mail: Graham.Nicholson@uts.edu.au
2 Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
* Author to whom correspondence should be addressed.
Review: Ciguatoxins: Cyclic Polyether Modulators of Voltage-gated Iion Channel Function
Mar. Drugs 2006, 4, 82-118 (PDF format 502 K)

Open Access (open access to this paper was granted by MDPI)
Richard T. Layer 1,* and J. Michael McIntosh 2
1 Cognetix, Inc., 421 Wakara Way, Suite 201, Salt Lake City, UT 84108, USA
Phone: (801) 581-0400, Fax: (801) 581-9555, E-mail: rlayer@cognetix.com
2 Department of Psychiatry and Department of Biology, University of Utah, 257 S. 1400 E., Salt Lake City, UT 84112, USA
Phone: (801) 585-3622, Fax: (801) 585-5010, E-mail: mcintosh.mike@gmail.com
* Author to whom correspondence should be addressed.
Review: Conotoxins: Therapeutic Potential and Application
Mar. Drugs 2006, 4, 119-142 (PDF format 125 K)

Open Access
Shana L. Geffeney 1,2 and Peter C. Ruben 1,*
1 Department of Biology, Utah State University, 5305 Old Main Hill, Logan, Utah, 84322-5305, USA
+01-435-797-2490 (voice), +01-435-494-1575 (fax), pruben@biology.usu.edu
2 Present address: Department of Molecular and Cellular Physiology, Stanford University, 279 Campus
Drive, Beckman Center B115, Stanford, California, 94305, USA
* Author to whom correspondence should be addressed.
Review: The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels
Mar. Drugs 2006, 4, 143-156 (PDF format 91 K)

Open Access
Ahmed Al-Sabi #, Jeff McArthur #, Vitaly Ostroumov # and Robert J. French *
Hotchkiss Brain Institute and the Department of Physiology and Biophysics, University of Calgary,
3330 Hospital Drive N.W., Calgary, Alberta, Canada T2N 4N1
# These authors contributed equally to this article.
* Corresponding author: Tel: 1 403 220 6893. Fax: 1 403 283 8731. E-mail: french@ucalgary.ca
Review: Marine Toxins That Target Voltage-gated Sodium Channels
Mar. Drugs 2006, 4, 157-192 (PDF format 925 K)

Open Access (open access to this paper was granted by MDPI)
Christina I. Schroeder and Richard J. Lewis*
Institute for Molecular Bioscience, The University of Queensland, St Lucia, 4072, QLD, Australia
E-mail: t.schroeder@imb.uq.edu.au (for Christina I. Schroeder)
* To whom correspondence should be addressed. Tel: +61-7-3346 2984; Fax: +61-7-3346 2101.
E-mail: r.lewis@imb.uq.edu.au
Review: ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical Potential
Mar. Drugs 2006, 4, 193-214 (PDF format 419 K)

Open Access (open access to this paper was granted by MDPI)
Lei Wen 1,2, Sheng Yang 1, Wenxia Zhou 1, Yongxiang Zhang 1,* and Peitang Huang 3
1 Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
2 School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
3 Beijing Institute of Biotechnology, Beijing 100071, China
* Author to whom correspondence should be addressed: Tel. (86)-10-66931625; Fax (86)-10-
68211656; E-mail: zhangyx@nic.bmi.ac.cn
Review: New Conotoxin SO-3 Targeting N-type Voltage-Sensitive Calcium Channels
Mar. Drugs 2006, 4, 215-227 (PDF format 232 K)

Open Access (open access to this paper was granted by MDPI)
Susan Wonnacott 1,* and Timothy Gallagher 2
1 Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
E-mail: bsssw@bath.ac.uk
2 School of Chemistry, University of Bristol, Bristol BS8 1TS, United Kingdom
E-mail: T.Gallagher@bristol.ac.uk
* Author to whom correspondence should be addressed.
Review: The Chemistry and Pharmacology of Anatoxin-a and Related Homotropanes with respect to Nicotinic Acetylcholine Receptors
Mar. Drugs 2006, 4, 228-254 (PDF format 186 K)

Open Access
William Kem 1,*, Ferenc Soti 1, Kristin Wildeboer 1, Susan LeFrancois 1, Kelly MacDougall 1, Dong-Qing Wei 3, Kuo-Chen Chou 4 and Hugo R. Arias 2
1 Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, FL 32610-0267, USA
2 Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766-1854, USA
3 College of Life Science and Technology, Shanghai Jiaotong University, Minhang District Shanghai, 200240, China
4 Gordon Life Science Institute, San Diego, CA 92130, USA
* Authors to whom correspondence should be addressed; Tel. (352) 392-3541; Fax (352) 392-9696; Email: Kem@pharmacology.ufl.edu
Review: The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties
Mar. Drugs 2006, 4, 255-273 (PDF format 210 K)

Issue 4  (December 2006) 274-297


Open Access (open access to this paper was granted by MDPI)

Vipra Kundoor 1, Xiaoying Zhang 1, Sherief Khalifa 2, Hesham Fahmy 1,*, and Chandradhar Dwivedi 1,*
1 Department of Pharmaceutical Sciences, South Dakota State University, Brookings, SD 57007, USA. Tel.: 605-688-4247, Fax 605-688-5993
2 Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
* Author to whom correspondence should be addressed
Received: 28 July 2006 / Accepted: 18 August 2006 / Published: 21 August 2006

Full Original Paper: A Possible Mechanism of Action of the Chemopreventive Effects of Sarcotriol on Skin Tumor Development in CD-1 Mice
Mar. Drugs 2006, 4, 274-285 (PDF format 96 K)


Open Access (open access to this paper was granted by MDPI)
Leonardo Castellanos 1, Carmenza Duque 1, Jaime Rodríguez 2 and Carlos Jiménez 2,*
1 Departamento de Química, Universidad Nacional de Colombia, AA 14490 Bogo á, Colombia
2 Departamento de Química Fundamental, Facultad de Ciencias, Campus da Zapateira Universidad de
A Coruña, 15071 A Coruña, Spain
* Author to whom correspondence should be addressed: Tel: +34-981167000 Ext. 2170, Fax: +34-981 167065; E-mail: carlosjg@udc.es

Short Communication: Synthesis of Acetylhomoagmatine
Mar. Drugs 2006, 4, 286-289 (PDF format 50 K)

Open Access
Michio Namikoshi 1,*, Takeshi Fujiwara 2, Teruaki Nishikawa 3 and Kazuyo Ukai 1
1 Tohoku Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan
E-mail: mnami@tohoku-pharm.ac.jp (M. N.). E-mail: ukai_k@tohoku-pharm.ac.jp (K. U.)
2 Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan
E-mail: megadeus0145@hotmail.com (T. F.).
3 The Nagoya University Museum, Chikusa-ku, Nagoya 464-8601, Japan
E-mail: nishikawa@num.nagoya-u.ac.jp (T. N.).
* Author to whom correspondence should be addressed. Tel., +81-22-727-0219; fax, +81-22-727-0218; e-mail, mnami@tohoku-pharm.ac.jp.
Received: 19 September 2006 / Accepted: 31 October 2006 / Published: 1 November 2006

Full Paper: Natural Abundance 14C Content of Dibutyl Phthalate (DBP) from Three Marine Algae
Mar. Drugs 2006, 4, 290-297 (PDF format 48 K)


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